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    Coenzyme Q10

    CoEnzymeCoenzyme Q10 is an essential nutrient that is found in every living cell in the body. CoQ10 is intimately involved in the synthesis of Adenosine TriPhosphate (ATP), the basic respiratory energy molecule in the mitochondria of every cell, and so in generation of 95 percent of the body’s energy. It helps the body’s cells convert food and oxygen into ATP, a chemical that all tissues require to function properly. The involvement of coenzyme Q10 as a Redox carrier of the respiratory chain is also well established1. Most human CoQ10 is synthesized by the liver.

    Thousands of scientific papers published all over the world in the past three decades have examined its uses. Found in every cell in the body and for that reason often called ubiquinone, CoQ10 is especially plentiful in the LDL fractions of plasma and is as necessary for life as oxygen, food and water.

    For our bodies to synthesize CoQ10 from food requires adequate nutrition including ample vitamin B6 and selenium. Our ability to synthesize Coenzyme Q10 gradually diminishes with age by as much as 80 percent, and some researcher have linked the symptoms of aging to a chronic low level of CoQ10.

    A powerful antioxidant, this vitamin-like Coenzyme stops arrhythmias, ameliorates allergies, angina, cancer, oedema, hypertension, periodontal disease and helps dispose of excess body fat.[1] Given orally with vitamin B6, CoQ10 strengthens the immune system by elevating IgG and T4 lymphocytes.[2] More importantly, it is highly effective in gum disease because our gums require a lot of energy.

     

    CoEnzyme Q10 and the Heart

    The highest concentration of CoQ10 is in the heart. In congestive heart failure, the heart is unable to pump all the blood returned from the tissues. In clinical studies[3] Digitalis, diuretics and vasodilators yielded 25 percent survival after six years; CoQ10 without additional drugs, 75 percent.

    According to West et al[4] CoQ10 “nourishes and strengthens the heart muscle, relieves stress on blood vessels, promotes blood flow that is unhindered by sticky platelets and sludge, aids in the normal electrical activity of heartbeat, and encourages good tone throughout the circulatory tree.”

    In the U.S. it has been seriously used long-term in Indiana and Florida, but particularly in the Langsjoen Clinic in Tyler, Texas. They use CoQ10 along with the usual anticoagulant and blood pressure medications; they feel that using CoQ10 the conventional medications can frequently be reduced.

    In his paper3 Langsjoen concludes “CoQ10 is so basic that all health problems we do not understand should be re-evaluated.”

    Karl Folkers, who pioneered early research on CoQ10 as well as vitamin B6, considers it “nothing less than a potential medical breakthrough.” He says, “If you don’t have enough, you’re sick; without it you’re dead.”

     

    Coenzyme Q10 and Gum Disease

    CoEnzymeQ10 is extremely important in the repair and maintenance of periodontal tissue. Several studies show the correlation between PI and CoQ10 deficiencies. Coenzyme Q10 is also a powerful antioxidant and without enough Coq10 to boost resistance, a person’s periodontal damage may exceed repair 8,9,10 .

    Coenzyme Q10 has been shown to have a much more rapid and powerful effect when applied directly to the gums 6,7. Gum tissue will absorb sufficient quantities of Coenzyme Q10 to replenish deficiencies. Unlike other alternate supplements and medicines, the results of CoQ10 application are quickly observed 12.

    Researchers at OsakaUniversity faculty of dentistry in Japan found that people with gum disease tend to have significantly lower levels of CoQ10 in the tissues of their gums. They gave patients with moderately or severely inflamed gums a regimen of CoQ10 for about 8 weeks. Patients received no other therapy. The CoQ10 therapy effectively suppressed the gingival inflammation in every case.

    In another study performed in Japan, researchers compared the effect of topical application of CoenzymeQ10 to traditional therapy for patients with adult periodontitis. The results showed “significant reductions in gingival crevicular fluid flow and probing depth”. When used in combination with traditional subgingival debridement, significant improvements in the modified gingival index bleeding on probing and peptidase activity (periodontopathic bacteria) were found. The authors concluded that the topical application of Coenzyme Q10 improved adult periodontitis nor only as a sole treatment but also in combination with traditional non-surgical periodontal therapy.

    A multitude of clinical studies have been performed in the last two decades, and a milestone publication by Karl Folkers shows an overwhelming body of evidence for the effects of Coenzyme Q10 in fighting periodontal disease.

    A commercially available version of CoenzymeQ10 for topical application on oral gum tissue is called PerioQ. This product contains a proprietary absorption enhanced matrix of Coenzyme Q10 in a vegetable glycerin base, without any artificial color or taste additives.

    More information on this product is available at www.perioq.com.

     

    REFERENCES:

    1. Bliznakov EG, Hunt ER The Miracle Nutrient: Coenzyme Q10,New York: Bantam,(1988)

    2. Folkers, K., A Critique of 25 years of Research which culminated in the successful therapy of periodontal disease with CoenzymeQ10, Journal of Dental Health, 42:258-263, July 1992.

    3. Folkers K et al. The activities of Coenzyme Q10 and vitamin B6 for immune response, Biochem. Biophys. Research Comm. 1993;193:88-92.

    4. Langsjoen PH. et al. Long-term effectiveness and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy, Am. J. Cardiol. 1990;65:521-523.

    5. West B. Health Alert 1994;Jan.

    6. Hanioka T; Tanaka M; Ojima M; Shizukuishi S: Effect of topical application of coenzyme Q10 an adult periodontitis. Mol Aspects Med: 15s:241-248 (1994)

    7. Nylander M; Nordlund M: Response of periodontitis to therapy with coenzyme Q10.8th Int.Symp. Biomed. and Clin.Aspects of CoQ10: 37 (1993)

    8. Hansen et al. 1976 Bioenergetics in Clinical Therapy. Gingival and leucocytic deficiencies of Coenzyme Q10 in patients with periodontal disease. Res Commun Chem Pathol Pharmacol 14(4): 729-738

    9. Matsumura, et al. 1973. Evidence for enhanced treatment of periodontal disease by therapy with coenzyme Q. Int J Vitam Nutr Res 43 (4):537-548

    10. Nakamura, et al. 1974. Study of Coenzyme Q in gingival of patients with periodontal disease and evidence for a deficiency of conenzyme Q10. Proc Natt Acad Sci 71:1456

    11. Wilkinson et al. 1977. Treatment of periodontal and other soft tissue diseases of the oral cavity with Coenzyme Q.  Biomedical and Clinical Aspects of Coenzyme Q. vol 3, Amsterdam: Elsevier/North Holland Biomedical Press.

    12. Emile, et al. 1987 The Miracle Nutrient CoEnzymeQ10 Bantam Books, New York,.